We study fundamental colloid and surface science and its applications to areas of biomedical and biotechnological interest. In particular, we focus on the biophysical study of lung surfactant and other self-assembled phospholipid/protein monolayers/bilayers/multilayers; pulmonary toxicology of nanomaterials and nanoparticle-based pulmonary drug delivery; and the development of advanced surface tension and contact angle measurement methodologies. The techniques we use include Atomic Force Microscopy (AFM), Langmuir-Blodgett (LB) technique, and drop shape analysis. The goal of our study is to explore the fundamental nature of biocolloids and biointerfaces, and to apply this knowledge to biomedical and clinical practices through an interdisciplinary and translational approach.