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University of Hawai’i

John A. Burns School of Medicine

Department of Cell and

Molecular Biology


Rondé, P., Dougherty, J.J. and Nichols, R.A. (2000) Functional IP3- and ryanodine-sensitive calcium

     stores in presynaptic varicosities of NG108-15 (rodent neuroblastoma X glioma hybrid) cells.

     J. Physiol., 529, 307-319. PMID: 11101642

Nayak, S.V., Rondé, P., Spier, A.D., Lummis, S.C.R. and Nichols, R.A. (2000) Nicotinic receptors co-

     localize with 5-HT3 serotonin receptors on striatal nerve terminals. Neuropharmacol., 39,

     2681-2690.  PMID: 11044738

Rondé, P. and Nichols, R.A. (2001) Postsynaptic target regulates the functional properties of

     presynaptic 5-HT3 receptors on axonal varicosities of NG108-15 hybrid neuroblastoma cells.

     Neurosci., 102, 979-987.   PMID: 11182259

Nayak, S.V., Dougherty, J.J., McIntosh, J.M. and Nichols, R.A. (2001) Ca2+ changes induced by different

     presynaptic nicotinic receptors in separate populations of individual striatal nerve terminals.  

     J.  Neurochem., 76, 1860-1870.   PMID: 11259504

van Hooft, J.A., Dougherty, J.J., Endeman, D., Nichols, R.A. and Wadman, W.J. (2002) Gabapentin

     inhibits presynaptic Ca2+ influx and synaptic transmission in rat hippocampus and neocortex.

     Eur. J. Pharmacol. 449, 221-228.  PMID: 12167463

Dougherty, J.J., Wu, J. and Nichols, R.A. (2003) Beta amyloid regulation of presynaptic nicotinic

     receptors in rat hippocampus and neocortex. J. Neurosci., 23, 6740-6747.  PMID: 12890766

Nichols, R.A., Dougherty, J.J., Choi, C.H. and Wu, J. (2004) Beta amyloid regulation of murine

     presynaptic nicotinic receptors. Neurobiol. Aging, 25, 392.

Wu, J., Dougherty, J.J. and Nichols, R.A. (2006) Dopamine receptor regulation of Ca2+ levels in

     individual nerve terminals from rat striatum: comparison of presynaptic D1-like and D2-like

     receptors. J. Neurochem., 98. 481-494.  PMID: 16805841

Nichols, R.A., Dengler, A., Nakagawa, E., Bashkin, M., Paul, B.T., Wu, J. and Khan, G.M. (2007) A

     constitutive, TRP-like Ca2+ influx pathway in presynaptic nerve endings independent of voltage-

     gated Ca2+ channels and Na+/Ca2+ exchange. J. Biol. Chem., 282, 36102-36111.  PMID: 17928293

Wu, J., Khan, G.M. and Nichols, R.A. (2007) Dopamine release in prefrontal cortex in response to beta

     amyloid activation of alpha7 nicotinic receptors. Brain Res., 1182, 82-89.  PMID: 17935702

Dougherty, J.J., Wu, J., Mehta, T., Brown, B. and Nichols, R.A. (2008) Chronic nicotine alters nicotinic

    receptor-induced presynaptic Ca2+ responses in isolated nerve terminals, Neurochem. Res., 33,

    1106-1112.  MID: 18095155

Mehta, T.K., Dougherty, J.J., Wu, J., Choi, C.H., Ghous, G.M and Nichols, R.A. (2009) Defining

     presynaptic nicotinic receptors regulated by beta amyloid in mouse cortex and hippocampus with

     receptor null mutants, J. Neurochem., 109, 1452-1458. PMID: 19457164

Dougherty, J.J. and Nichols, R.A. (2009) Cross-desensitization between colocalized nicotinic

     acetylcholine receptors and 5-HT3 receptors on presynaptic nerve terminals. Acta Pharmacol. Sinica,

     30, 788-794 (invited contribution). PMID: 19498419

Khan, G.M., Tong, M., Jhun, M., Arora, K. and Nichols, R.A. (2010) Beta-Amyloid activates presynaptic alpha7

     nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts.

     Eur J Neurosci. 31, 788-96. PMID: 20374280

Khan, G.M., Wang, H.Y., Puzzo, D., Arancio, O. and Nichols, R.A. Beta amyloid: neuromodulator and

     toxic fragment, in preparation.

Yang, K., Buhlman, L., Khan, G.M., Nichols, R.A., Jin, G., McIntosh, J.M., Whiteaker, P., Lukas, R.J. and Wu. J.

     (2011) Functional alpha6-containing nicotinic acetylcholine receptors on presynaptic GABAergic boutons 

      mediate cholinergic modulation of VTA dopamine neurons. J. Neurosci., 31, 2537-2548. PMID: 213255521

Tong, M., White, M.M., Arora, K., and Nichols, R.A. (2011) Role of key aromatic residues in the ligand-

      binding domain of alpha7 nicotinic receptors in the agonist-like action of beta amyloid. J. Biol.

      Chem., 286, 34373-34381. PMID: 21828053.

Pitts, M.W., Raman, A.V., Hashimoto, A.C., Todorovic, C., Nichols, R.A. and Berry, M.J. (2012) Deletion of

      selenoprotein P results in impaired function of parvalbumin interneurons and alterations in fear learning

      and sensorimotor gating. Neuroscience, 208, 58-68. PMID: 22640876

Arora, K., Alfulaij, N., Higa, J.K., Panee, J. and Nichols, R.A. (2013) Impact of sustained exposure to

      beta-amyloid on calcium homeostasis and neuronal integrity in a model nerve cell system

      expressing alpha4beta2 nicotinic acetylcholine receptors. J. Biol. Chem., 288, 11175-11190.

      PMID: 23479730

Tong, M.*, Lawrence, J.L.M.*, Sherrin, T., Alfulaij, N., Costarino, M., White, M.M., Bellinger, F.,

      Todorovic, C. and Nichols, R.A. Regulation of presynaptic Ca2+, synaptic plasticity and contextual

      fear conditioning by a N-terminal beta amyloid fragment. Proc. Natl Acad. Sci. USA


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