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University of Hawai’i

John A. Burns School of Medicine

Department of Cell and

Molecular Biology


Model: Presynaptic-like Varicosity

Showing relationship between nicotinic acetylcholine receptors (nAChR) and voltage gated calcium channels (VGCC).


Research in our laboratory is focused on the regulation of the presynaptic nerve terminal:

Beta amyloid (Aβ) regulation of presynaptic function

  1. Beta amyloid (Aβ)-induced neurotoxicity

Nicotine regulation via presynaptic nicotinic receptors

Calcium homeostasis


Last updated July, 2013

Copyright © 2013 Robert Nichols, Ph.D. All rights reserved.

Site design Michelle Jhun

Model: α7 Nicotinic Receptor

Shown with associated Lipid Raft on one side and Aβ oligomer (in grey circles).