[PUBMED]
ResearchGate


scope 2 Shi GX, Yang WS, Jin L, Matter ML, Ramos JW. RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases. Proc Natl Acad Sci U S A. 115(2):E190-E199. doi: 10.1073/pnas.1708584115. (2018)

scope 2 Greig FH, Kennedy S, Gibson G, Ramos JW, Nixon GF. PEA-15 (Phosphoprotein Enriched in Astrocytes 15) Is a Protective Mediator in the Vasculature and Is Regulated During Neointimal Hyperplasia. J Am Heart Assoc. 6(9). pii: e006936. doi: 10.1161/JAHA.117.006936. (2017)

scope 2 Doe J, Kaindl AM, Jijiwa M, de la Vega M, Hu H, Griffiths GS, Fontelonga TM, Barraza P, Cruz V, Van Ry P, Ramos JW, Burkin DJ, Matter ML. PTRH2 gene mutation causes progressive congenital skeletal muscle pathology. Hum Mol Genet. 15;26(8):1458-1464. doi: 10.1093/hmg/ddx048. (2017)

scope 2 Sulzmaier FJ, Young-Robbins S, Jiang P, Geerts D, Prechtl AM, Matter ML, Kesari S, Ramos JW. RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics. Oncotarget. 7(48):79869-79884. doi: 10.18632/oncotarget.13084. (2016)

scope 2 Fernández-Gallardo J, Elie BT, Sadhukha T, Prabha S, Sanaú M, Rotenberg SA, Ramos JW, Contel M. Heterometallic titanium-gold complexes inhibit renal cancer cells in vitro and in vivo. Chem Sci. 6(9):5269-5283. doi: 10.1039/C5SC01753J. (2015)

scope 2 G.S. Griffiths, A. Leychenko, J. Doe, M.Jijiwa, P. Van Ry, V. Cruz, M. De la Vega, J.W. Ramos, D.J. Burkin and M.L. Matter. Bit-1 is an essential regulator of myogenic differentiation. J. Cell Science. 128(9):1707-1717. Epub 2015 Mar 13. (2015)

scope 2 Z. Liang, F.J. Sulzmaier, W.Y. Yoshida, M. Kelly, J.W. Ramos and P.G. Williams. Neopetrocyclamine A-B, New Polycyclic Diamine Alkaloids from the Sponge Neopetrosia sp. J. Natural Products. 78(3):543-7. doi: 10.1021/np500759r. Epub 2015 Jan 13. (2015)

scope 2 Fernández-Gallardo J, Elie BT, Sulzmaier FJ, Sanaú M, Ramos JW, Contel M. Organometallic Titanocene-Gold Compounds as Potential Chemotherapeutics in Renal Cancer. Study of their Protein Kinase Inhibitory Properties. Organometallics. 33(22):6669-6681. (2014)

scope 2 Frik M, Martínez A, Elie BT, Gonzalo O, Ramírez de Mingo D, Sanaú M, Sánchez-Delgado R, Sadhukha T, Prabha S, Ramos JW, Marzo I, Contel M. In Vitro and in Vivo Evaluation of Water-Soluble Iminophosphorane Ruthenium(II) Compounds. A Potential Chemotherapeutic Agent for Triple Negative Breast Cancer. J Med Chem. 57(23):9995-10012. doi: 10.1021/jm5012337. (2014)

scope 2 Sharma A, Fonseca LL, Rajani C, Yanagida JK, Endo Y, Cline JM, Stone JC, Ji J, Ramos JW, Lorenzo PS. Targeted deletion of RasGRP1 impairs skin tumorigenesis. Carcinogenesis. May;35(5):1084-91. doi: 10.1093/carcin/bgu016. (2014)

scope 2 Sulzmaier FJ and Ramos JW. RSK isoforms in cancer cell invasion and metastasis. Cancer Res. 2013 Oct 15;73(20):6099-105. doi: 10.1158/0008-5472.CAN-13-1087. (2013)

scope 2 J.E. Gawecka, S.S. Young-Robbins, F.J. Sulzmaier, M.J. Caliva, M. Heikkilä, M.L. Matter, and J.W. Ramos. RSK2 suppresses integrin activation and fibronectin matrix assembly and promotes cell migration. J.Biol. Chem., 287(52): 43424-43437 (2012).

scope 2 F.J.Sulzmaier, Z. Li, M.L. Nakashige, D.M. Fish, W.J. Chain, J.W. Ramos. Englerin A selectively induces necrosis in human renal cells. PLOS ONE, 7(10):e48032. doi:10.1371/journal.pone.0048032 (2012)

scope 2 F.J. Sulzmaier, J. Opoku-Ansah, and J.W. Ramos. Phosphorylation determines if PEA-15 has pro- or anti-tumor effects. Small GTPases, 3(3):173-177 (2012). http://dx.doi.org/10.4161/sgtp.20021

review J.E. Gawecka and J.W. Ramos. Pea15. Encyclopedia of Signaling Molecules.pgs. 1358-1364. Choi, Sangdun, Ed. Springer (2012). ISBN 978-1-4419-0460-7

scope 2 J.E. Gawecka, D. Geerts, J. Koster, M.J. Caliva, F.J. Sulzmaier, J. Opoku-Ansah, R.K. Wada, A.S. Bachmann, and J.W. Ramos. PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma. Int J Cancer 131(7):1556-68. (2012). doi: 10.1002/ijc.27415.

scope 2 F.J. Sulzmaier, M.K. Valmiki, D.A. Nelson, M.J. Caliva, D. Geerts, M.L. Matter, E.P. White, J.W. Ramos. PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D. Oncogene 31(30):3547-60. (2012) Nov 21. doi: 10.1038/onc.2011.514.

scope 2 Z. Liang, A. Sorribas, F.J. Sulzmaier, J.I. Jiménez, W. Wang, T. Sauvage, W.Y. Yoshida, G. Wang, J.W. Ramos, P.G. Williams.Stictamides A-C, MMP12 Inhibitors Containing 4-Amino-3-hydroxy-5-phenylpentanoic Acid Subunits. J Org Chem. 76(10):3635-3643 (2011).(Featured Article)

scope 2 G.S. Griffiths, M. Grundl, A. Leychenko, S. Reiter, S.S. Young-Robbins, F.J. Sulzmaier, M.J. Caliva, J.W. Ramos and M.L. Matter. Bit-1 mediates integrin-dependent cell survival through activation of the NFkB pathway. J. Biol. Chem. 286(16):14713-23 (2011)

scope 2 I. Hunter, K.S. Mascall, J.W. Ramos and G.F. Nixon. A phospholipase Cg1-activated pathway regulates transcription in vascular smooth muscle cells. Cardiovasc Res. 90(3):557-64 (2011).

scope 2 S. Pastorino, H. Renganathan, M.J. Caliva, E.L. Filbert, J. Opoku-Ansah, F.J. Sulzmaier, J.E. Gawecka, G. Werlen, A.S. Shaw, J.W. Ramos. The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.FASEB J, 24(8):2818-28 (2010).

scope 2 J.E. Gawecka, G.S. Griffiths, B. Ek-Rylander, J.W. Ramos, M.L. Matter.  R-Ras regulates migration through an interaction with Filamin A in melanoma cells. PLoS ONE 5(6): e11269. doi:10.1371/journal.pone.0011269 (2010).

scope 2 J.W. Ramos, D.A. Townsend, D. Piarulli, S. Kolata, K. Light, G. Hale, and L.D. Matzel.  Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities. BMC Neuroscience, 10:134 (2009).   highly accessed

review M. Gudur Valmiki and J.W. Ramos.  Death Effector Domain-Containing Proteins. CMLS, 66(5):814-30 (2009). 

review2 J.W. Ramos.  The Regulation of Extracellular Signal-Regulated Kinase (ERK) in Mammalian Cells. IJBCB, 40(12):2707-2719 (2008).  -the 4th most downloaded IJBCB paper of 2009

 H. Vaidyanathan, J. Opoku-Ansah, S. Pastorino, H. Renganathan, M.L. Matter, and J.W. Ramos.  ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15. PNAS. 104(50): 19837-19842 (2007).  

  F. Renault-Mihara, F. Beuvon, X. Iturrioz, B. Canton, S. De Bouard, N. Léonard, S. Mouhamad, A. Sharif, J.W. Ramos, M-P. Junier, and H Chneiweiss.   PEA-15 Expression Inhibits Astrocyte Migration by a PKC Delta-Dependent Mechanism.   Mol. Biol. Cell, 17(12):5141-52 (2006).

   M.L. Matter and J.W. Ramos.   Expression cloning of signaling proteins regulated by cell adhesion.  Methods in Molecular Biology, vol. 341: Cell-Cell Interactions: Methods and Protocols.  Sean P. Colgan ed., Humana Press Inc, Totowa, NJ. (2006).

  H. Renganathan, H. Vaidyanathan, A. Knapinska and J.W. Ramos.  Phosphorylation of PEA-15 Switches its Binding Specificity from ERK MAP kinase to FADD.  Biochem J. 390(3):729-735 (2005). 

H. Vaidyanathan and J.W. Ramos.   Rsk2 activity is regulated by its association with PEA-15.  J. Biol. Chem.  278(34):32367-32372 (2003). 

  J.M. Hill, H. Vaidyanathan, J.W. Ramos, M.H. Ginsberg and M.H. Werner.  Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain.  EMBO J  21(23):6494-6504 (2002). 

  M.L. Matter, M.H. Ginsberg, and J.W. Ramos.  Identification of cell signaling molecules by expression cloning.  Science's STKE, 2001 (103), pl9. (doi: 10.1126/stke.2001.103.pl9) (2001).

  J.W. Ramos *‡, E. Formstecher *, M. Fauquet, D.A. Calderwood, J-C. Hsieh, B. Canton, X-T. Nguyen, J-V. Barnier, J. Camonis,  M.H. Ginsberg, and H. Chneiweiss ‡.   PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase.  Developmental Cell 1:239-250 (2001).  *Co-first authors, ‡Communicationg authors. 

  Y. Zhang, O. Redina, Y.M. Altshuller, M. Yamazaki, J. Ramos, H. Chneiweiss, Y. Kanaho, M.A. Frohman.  Regulation of PLD1 and PLD2 expression levels by PEA-15, a novel PLD-interacting protein. J.Biol.Chem. 275:35224-35232 (2000). 

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