scope 2 J. Fernández-Gallardo, B.T. Elie, T. Sadhukha, S. Prabha, M. Sanau, S.A. Rotenberg, J.W. Ramos, and María Contel. Heterometallic titanium-gold complexes inhibit renal cancer cells in vitro and in vivo. Chemical Science. DOI: 10.1039/c5sc01753j In Press. (2015)

scope 2 G.S. Griffiths, A. Leychenko, J. Doe, M.Jijiwa, P. Van Ry, V. Cruz, M. De la Vega, J.W. Ramos, D.J. Burkin and M.L. Matter. Bit-1 is an essential regulator of myogenic differentiation. J. Cell Science. 128(9):1707-1717. Epub 2015 Mar 13. (2015)

scope 2 Z. Liang, F.J. Sulzmaier, W.Y. Yoshida, M. Kelly, J.W. Ramos and P.G. Williams. Neopetrocyclamine A-B, New Polycyclic Diamine Alkaloids from the Sponge Neopetrosia sp. J. Natural Products. 78(3):543-7. doi: 10.1021/np500759r. Epub 2015 Jan 13. (2015)

scope 2 Fernández-Gallardo J, Elie BT, Sulzmaier FJ, Sanaú M, Ramos JW, Contel M. Organometallic Titanocene-Gold Compounds as Potential Chemotherapeutics in Renal Cancer. Study of their Protein Kinase Inhibitory Properties. Organometallics. 33(22):6669-6681. (2014)

scope 2 Frik M, Martínez A, Elie BT, Gonzalo O, Ramírez de Mingo D, Sanaú M, Sánchez-Delgado R, Sadhukha T, Prabha S, Ramos JW, Marzo I, Contel M. In Vitro and in Vivo Evaluation of Water-Soluble Iminophosphorane Ruthenium(II) Compounds. A Potential Chemotherapeutic Agent for Triple Negative Breast Cancer. J Med Chem. 57(23):9995-10012. doi: 10.1021/jm5012337. (2014)

scope 2 Sharma A, Fonseca LL, Rajani C, Yanagida JK, Endo Y, Cline JM, Stone JC, Ji J, Ramos JW, Lorenzo PS. Targeted deletion of RasGRP1 impairs skin tumorigenesis. Carcinogenesis. May;35(5):1084-91. doi: 10.1093/carcin/bgu016. (2014)

scope 2 Sulzmaier FJ and Ramos JW. RSK isoforms in cancer cell invasion and metastasis. Cancer Res. 2013 Oct 15;73(20):6099-105. doi: 10.1158/0008-5472.CAN-13-1087. (2013)

scope 2 J.E. Gawecka, S.S. Young-Robbins, F.J. Sulzmaier, M.J. Caliva, M. Heikkilä, M.L. Matter, and J.W. Ramos. RSK2 suppresses integrin activation and fibronectin matrix assembly and promotes cell migration. J.Biol. Chem., 287(52): 43424-43437 (2012).

scope 2 F.J.Sulzmaier, Z. Li, M.L. Nakashige, D.M. Fish, W.J. Chain, J.W. Ramos. Englerin A selectively induces necrosis in human renal cells. PLOS ONE, 7(10):e48032. doi:10.1371/journal.pone.0048032 (2012)

scope 2 F.J. Sulzmaier, J. Opoku-Ansah, and J.W. Ramos. Phosphorylation determines if PEA-15 has pro- or anti-tumor effects. Small GTPases, 3(3):173-177 (2012). http://dx.doi.org/10.4161/sgtp.20021

review J.E. Gawecka and J.W. Ramos. Pea15. Encyclopedia of Signaling Molecules.pgs. 1358-1364. Choi, Sangdun, Ed. Springer (2012). ISBN 978-1-4419-0460-7

scope 2 J.E. Gawecka, D. Geerts, J. Koster, M.J. Caliva, F.J. Sulzmaier, J. Opoku-Ansah, R.K. Wada, A.S. Bachmann, and J.W. Ramos. PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma. Int J Cancer 131(7):1556-68. (2012). doi: 10.1002/ijc.27415.

scope 2 F.J. Sulzmaier, M.K. Valmiki, D.A. Nelson, M.J. Caliva, D. Geerts, M.L. Matter, E.P. White, J.W. Ramos. PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D. Oncogene 31(30):3547-60. (2012) Nov 21. doi: 10.1038/onc.2011.514.

scope 2 Z. Liang, A. Sorribas, F.J. Sulzmaier, J.I. Jiménez, W. Wang, T. Sauvage, W.Y. Yoshida, G. Wang, J.W. Ramos, P.G. Williams.Stictamides A-C, MMP12 Inhibitors Containing 4-Amino-3-hydroxy-5-phenylpentanoic Acid Subunits. J Org Chem. 76(10):3635-3643 (2011).(Featured Article)

scope 2 G.S. Griffiths, M. Grundl, A. Leychenko, S. Reiter, S.S. Young-Robbins, F.J. Sulzmaier, M.J. Caliva, J.W. Ramos and M.L. Matter. Bit-1 mediates integrin-dependent cell survival through activation of the NFkB pathway. J. Biol. Chem. 286(16):14713-23 (2011)

scope 2 I. Hunter, K.S. Mascall, J.W. Ramos and G.F. Nixon. A phospholipase Cg1-activated pathway regulates transcription in vascular smooth muscle cells. Cardiovasc Res. 90(3):557-64 (2011).

scope 2 S. Pastorino, H. Renganathan, M.J. Caliva, E.L. Filbert, J. Opoku-Ansah, F.J. Sulzmaier, J.E. Gawecka, G. Werlen, A.S. Shaw, J.W. Ramos. The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.FASEB J, 24(8):2818-28 (2010).

scope 2 J.E. Gawecka, G.S. Griffiths, B. Ek-Rylander, J.W. Ramos, M.L. Matter.  R-Ras regulates migration through an interaction with Filamin A in melanoma cells. PLoS ONE 5(6): e11269. doi:10.1371/journal.pone.0011269 (2010).

scope 2 J.W. Ramos, D.A. Townsend, D. Piarulli, S. Kolata, K. Light, G. Hale, and L.D. Matzel.  Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities. BMC Neuroscience, 10:134 (2009).   highly accessed

review M. Gudur Valmiki and J.W. Ramos.  Death Effector Domain-Containing Proteins. CMLS, 66(5):814-30 (2009). 

  J.W. Ramos.  Pea15a. UCSD-Nature Molecule Pages.(doi:10.1038/mp.a002536.01) (2008).

review2 J.W. Ramos.  The Regulation of Extracellular Signal-Regulated Kinase (ERK) in Mammalian Cells. IJBCB, 40(12):2707-2719 (2008).  -the 4th most downloaded IJBCB paper of 2009

  S. Pastorino and J.W. Ramos.  Glioma: Challenges and new insights in the development of effective therapies. Hawaii Medical Journal. 67:20-23 (2008). 

 H. Vaidyanathan, J. Opoku-Ansah, S. Pastorino, H. Renganathan, M.L. Matter, and J.W. Ramos.  ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15. PNAS. 104(50): 19837-19842 (2007).  

  F. Renault-Mihara, F. Beuvon, X. Iturrioz, B. Canton, S. De Bouard, N. Léonard, S. Mouhamad, A. Sharif, J.W. Ramos, M-P. Junier, and H Chneiweiss.   PEA-15 Expression Inhibits Astrocyte Migration by a PKC Delta-Dependent Mechanism.   Mol. Biol. Cell, 17(12):5141-52 (2006).

   M.L. Matter and J.W. Ramos.   Expression cloning of signaling proteins regulated by cell adhesion.  Methods in Molecular Biology, vol. 341: Cell-Cell Interactions: Methods and Protocols.  Sean P. Colgan ed., Humana Press Inc, Totowa, NJ. (2006).

  H. Renganathan, H. Vaidyanathan, A. Knapinska and J.W. Ramos.  Phosphorylation of PEA-15 Switches its Binding Specificity from ERK MAP kinase to FADD.  Biochem J. 390(3):729-735 (2005). 

   J.W. Ramos.  PEA-15 Phosphoprotein: a potential cancer drug target. Hawaii Medical Journal. 64:77-79 (2005).  

  R. Sur and J.W. Ramos.  Vanishin is a novel ubiquitinylated death effector domain protein that blocks ERK activation.  Biochem J. 387(2):315-324 (2005).

F-L. Chou, J. M. Hill, J-C. Hsieh, J. Pouyssegur, A. Brunet, A. Glading, F. Überall, J.W. Ramos, M.H. Werner, and M.H. Ginsberg PEA-15 binding to ERK1/2 MAP kinases is required for its modulation of integrin activation.  J. Biol. Chem.  278(52):52587-52597 (2003). 

H. Vaidyanathan and J.W. Ramos.   Rsk2 activity is regulated by its association with PEA-15.  J. Biol. Chem.  278(34):32367-32372 (2003). 

  J.M. Hill, H. Vaidyanathan, J.W. Ramos, M.H. Ginsberg and M.H. Werner.  Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain.  EMBO J  21(23):6494-6504 (2002). 

  J.W. Ramos and M.H. Ginsberg.    Expression cloning strategies for the identification of adhesion molecules.  Methods in Cell-matrix adhesion.  Josephine Adams ed., Academic Press (2002).

  M.L. Matter, M.H. Ginsberg, and J.W. Ramos.  Identification of cell signaling molecules by expression cloning.  Science's STKE, 2001 (103), pl9. (doi: 10.1126/stke.2001.103.pl9) (2001).

  J.W. Ramos *‡, E. Formstecher *, M. Fauquet, D.A. Calderwood, J-C. Hsieh, B. Canton, X-T. Nguyen, J-V. Barnier, J. Camonis,  M.H. Ginsberg, and H. Chneiweiss ‡.   PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase.  Developmental Cell 1:239-250 (2001).  *Co-first authors, ‡Communicationg authors. 

  Y. Zhang, O. Redina, Y.M. Altshuller, M. Yamazaki, J. Ramos, H. Chneiweiss, Y. Kanaho, M.A. Frohman.  Regulation of PLD1 and PLD2 expression levels by PEA-15, a novel PLD-interacting protein. J.Biol.Chem. 275:35224-35232 (2000). 

  J.W. Ramos, P.E. Hughes, M.W. Renshaw, H. Chneiweiss, and M.H. Ginsberg.  The Death Effector Domain Protein, PEA-15, potentiates Ras activation of ERK by an adhesion independent mechanism.  Mol.Biol.Cell. 11:2863-72(2000).  

  C.A. Fenczik, J.W. Ramos, and M.H. Ginsberg
.  Expression cloning of proteins that modify integrin activation.  Signaling Through Cell Adhesion Molecules.  Jun-Lin Guan ed., CRC Press, pgs. 235-243 (1999).

  J.W. Ramos, T.J. Kojima, P.E. Hughes, C.A. Fenczik, and M.H. Ginsberg.  The Death Effector Domain of PEA-15 is involved in its regulation of integrin activation. J. Biol. Chem. 273:33897-33900 (1998). 

  C.A. Fenczik, T. Sethi, J.W. Ramos, P.E. Hughes, and M.H. Ginsberg.  Complementation of dominant suppression implicates CD98 in integrin activation.  Nature 390:81-85 (1997). 

  J.W. Ramos, C.A. Whittaker, and D.W. DeSimone.  Integrin-dependent adhesive activity is spatially controlled by inductive signals at gastrulation.  Development  122:2873-2883 (1996). 

  J.W. Ramos and D.W. DeSimone.  Xenopus embryonic cell adhesion to fibronectin: position-specific activation of RGD/synergy-site-dependent migratory behavior at gastrulation. J. Cell Biology 134:227-240 (1996).  

  D. Alfandari,  J. Ramos, L. Clavilier, D.W. DeSimone, and T. Darribere.  The RGD-dependent and Hep II binding domains of fibronectin govern the adhesive behavior of amphibian embryonic cells.  Mech. of Development.  56:83-92 (1996). 

  K. Danker, H. Hacke, J. Ramos, D.W. DeSimone, and D. Wedlich.  V+ Fibronectin expression and localization prior to gastrulation in Xenopus laevis embryos. Mech. of Development 44:155-165 (1993).

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